alpha actinin 3 deficiency

Powered by Restream This study suggests people with alphaactinin3 deficiency, or the lossoffunction ACTN3 gene variant, have a better cold tolerance thanks to their slowtwitch muscle fibers. Slowtwitch fibers generate heat effectively. People with an actinin3 deficiency do not shiver during cold exposure. Instead, they save energy by increasing their muscle tone, Westerblad says. For their experiments, the researchers recruited 42 male residents from Kaunas, a city in southern Lithuania with either the functioning ACTN3 or the gene variant. They were between the ages of 18 to 40 and led a moderately active lifestyle of 2 hours of exercising a week.