Ruslan Medzhitov ( Yale, HHMI): The Role of Toll Like Receptors in the Control of Adaptive Immunity

In this discovery talk, Dr. Ruslan Medzhitov provides a historical perspective that frames his involvement in the discovery of TollLike Receptors. Talk Overview: When he was a graduate student, Dr. Ruslan Medzhitov read a theory written by Dr. Charles Janeway that foresaw the existence of a set of receptors that would directly detect pathogens and signal to T and Bcells to generate an immune response (adaptive immunity). Medzhitov was determined to find such receptors In this discovery talk, Dr. Ruslan Medzhitov provides a historical perspective that frames his involvement in the discovery of TollLike Receptors. By following the clue that NFkB was involved in the immune response, he searched for receptors, like Toll, that had the capacity to activate NFkB.