Robert Lefkowitz ( Duke University) Part 2: Beta arrestins

In part 2 of the lecture, recent discoveries about how Betaarrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Betaarrestin mediated pathways, so called biased agonists